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Oracle has been named a Leader in the 2026 Gartner Magic Quadrant for Supply Chain Management Suites. The recognition is based on Oracle's Ability to Execute and Completeness of Vision for its Fusion Cloud Supply Chain & Manufacturing platform. Oracle also ranked first in three use cases in the 2026 Gartner Critical Capabilities for Supply Chain Management Suites report: Product-Centric, Services-Centric, and Distribution-Centric Supply Chain. The company's platform combines supply chain data with Fusion Agentic Applications that can sense, reason, decide, coordinate, and execute to meet business objectives. Oracle Cloud SCM connects supply chain processes across planning, procurement, manufacturing, maintenance, logistics, and order management on a single AI-powered cloud platform. The solution enables organisations to continuously monitor conditions, assemble context, identify disruptions, and recommend decisions whilst keeping supply chain professionals accountable for outcomes.

Oracle (ORCL) stock rallies 3% after Citi calls decline overdone. Key highlights. Table of Contents * Shares of Oracle climbed 2.84% to reach $148.87 during Wednesday's session, marking back-to-back gains * Citigroup initiated a 90-day positive catalyst watch on ORCL while maintaining its Buy recommendation and $330 target * Citi's Tyler Radke attributed the recent decline to investor capitulation combined with technical selling dynamics * Company executives at Deutsche Bank's Tech Conference highlighted strong cloud infrastructure adoption among major enterprise customers * Wall Street analysts collectively rate the stock as a Strong Buy, projecting an average target of $257.79 according to TipRanks Shares of Oracle (ORCL) finished Wednesday's trading session at $148.87, advancing 2.84% while broader indices remained under pressure. The S&P 500 edged down 0.02% and the Dow Jones Industrial Average declined 0.21%. The upward momentum followed an announcement from Citigroup analyst Tyler Radke, who added the software giant to a 90-day positive catalyst watch list. Radke maintained his Buy stance with a $330 price objective, representing potential gains of approximately 122% from Wednesday's closing price. According to Radke's assessment, the recent share price weakness exceeded rational levels. He identified investor capitulation and technical factors - including pressures related to credit spreads and at-the-market equity offerings - as primary contributors to the downturn. However, Citi believes the fundamental outlook is strengthening. The firm highlighted accelerating artificial intelligence demand and favorable trends for margins and pricing throughout the cloud infrastructure sector. Currently, Oracle trades 56.94% beneath its 52-week peak of $345.72, reached on September 10th. This substantial discount has prompted several analysts to reassess the risk-reward equation more favorably. Positive messaging at Deutsche Bank event. During Wednesday's proceedings, Oracle presented at the Deutsche Bank Technology Conference. Management emphasized that its cloud infrastructure platform is generating tangible outcomes for major enterprise customers. These remarks helped alleviate investor worries regarding Oracle's substantial debt obligations, incurred to construct AI infrastructure for strategic partners such as Microsoft and OpenAI. Citigroup observed that robust AI-driven demand patterns could trigger upward analyst estimate revisions before Oracle releases earnings and hosts its investor day in late October. Improving technical indicators. According to TipRanks' Technical Analysis platform, ORCL currently displays a Buy signal. The composite assessment incorporates 10 bullish indicators, five neutral readings, and seven bearish signals. The shares are positioned above their 20-day exponential moving average of $143.31, generating a bullish technical signal. Additionally, the Williams %R momentum indicator registers a Buy, indicating the stock isn't overextended and has capacity for further appreciation. The Rate of Change metric registers 0.26%, validating an upward trend. Meanwhile, the Relative Strength Index reads 51.19, positioning ORCL within neutral momentum territory. From an analyst perspective, TipRanks data reveals a Strong Buy consensus derived from 28 Buy recommendations and four Hold ratings issued during the past three months. The consensus price target stands at $257.79, suggesting 73% appreciation potential from present levels. Wednesday's session saw 17.9 million shares change hands, significantly below the 50-day average volume of 32.4 million. Oracle outpaced technology sector peers during the session, with Microsoft advancing 0.95% while Alphabet's Class A and C shares declined 1.43% and 1.23% respectively. Limited Time Offer Get 3 free stock ebooks. Discover top-performing stocks in AI, Crypto, and Technology with expert analysis. * Top 10 AI Stocks - Leading AI companies * Top 10 Crypto Stocks - Blockchain leaders * Top 10 Tech Stocks - Tech giants

Tufts model estimates 82x ROI and up to $21 million in value from Medable AI agent. Tufts Center for the Study of Drug Development (CSDD) and clinical trial platform company Medable recently announced an analysis estimating that Medable's Clinical Monitoring Agent could deliver an 82x return on investment for phase 3 trials and 64x for phase 2. Based on expected net present value (eNPV), that equated to roughly $21 million in added financial value for phase 3 and $7.5 million for phase 2. The analysis focused on oncology. The analysis comes as enterprise use of agents is surging, and many organizations are using agents for workflows ranging from coding to tackling routine business workflows. McKinsey reported in July that 93% of its survey respondents reported exceeding AI budgets, while, 41% of software developers reported agents saved them one to two hours per day, on average, according to IBM in late 2025. Meanwhile, in the clinical trial domain, a 2025 Tufts CSDD analysis of 36 company-reported AI/ML use cases found an average 18% reduction in cycle time, reporting the largest trial-execution gains in patient monitoring and enrollment assessments. Putting numbers on the pilots. The latest Tufts-Medable collaboration sought to translate those reported operational gains into the language of investment decisions. "We've known for some time that companies have been piloting AI enablement tools, but what they've often been lacking is any kind of quantification of the actual ROI, the value proposition," said Ken Getz, executive director of Tufts CSDD. "We were really interested in doing a study where we could put some hard numbers around a specific AI enablement solution." Dr. Pamela Tenaerts, Chief Medical Officer at Medable, sees the potential savings expanding for sponsors with sizable oncology portfolios. She projected an incremental portfolio eNPV of up to $226 million across phase 2 and 3 studies for sponsors with 20 active indications and up to $565 million for those with 50 indications based on modeled portfolio scenarios that apply the same estimated value across each indication. Prebuilt agents, then about 20% tweaking. While agents can tackle a range of workflows, their clinical-trial configuration varies from sponsor to sponsor. Medable starts with prebuilt monitoring and trial master file (TMF) agents with connectors to clinical, data and enterprise systems. Medable's connector page lists roughly 40 integrations, spanning EDC (Medidata Rave, Oracle InForm, Veeva EDC), eTMF and CTMS (Veeva), safety (Oracle Argus), randomization (Oracle IRT), warehouses (Snowflake, Databricks, BigQuery) and general enterprise tools (Slack, Teams, SharePoint-adjacent storage). Sponsors configure the agents depending on their needs. "A lot of those agents still need about 20% tweaking, because systems are different and it has to be configured," Tenaerts said. In a Medable demonstration reviewed by the author, the agent pulled together information from multiple clinical systems and flagged a site with unusually low adverse-event reporting alongside concomitant medications recorded without corresponding adverse events. It then recommended opening EDC queries and sending correspondence to the site. "It can also see across the sites that person has, whether that's a recurring issue or not," Tenaerts said. Wrangling millions of data points per protocol. The ability to find patterns in mountains of data efficiently remains a priority as phase 3 protocols now involve an average of 5.9 million data points, up from 929,000 in 2012, per the Tufts CSDD/TransCelerate analysis of 105 protocols across 15 sponsor companies. "As the number of items collected multiplies, imagine you're a CRA [clinical research associate] and you have a study," Tenaerts said. "Your job is to wrangle that data together and make sure it all makes sense... You have an EDC system that collects data around the actual protocol data. You have CTMS [Clinical Trial Management System], you have TMF, and the CRA has to put all that data together in context and decide what to focus on." Clinical trials can be difficult to optimize through iteration. Randomization compares groups under prespecified conditions, leaving unobserved how the same trial would have performed with a different endpoint, eligibility rule, dose or monitoring plan. Testing those alternatives generally requires another trial with new participants, more time and substantial capital. Meanwhile, in clinical trials, avoiding outright failures is, of course, a priority. According to a study published in Journal of Medicinal Chemistry, the cumulative failure rate of small-molecule cancer drug candidates has hovered around 95% during phase 1 through phase 3 for roughly three decades. The odds improve in phase 3, but, still, failures outnumber successes. For instance, a 2026 analysis of 824 phase 3 oncology drug trials registered from 2007 through 2023 found a success rate of 43.4% (358 out of 824 trials). Can agents help with clinical trial failures? A host of problems are behind those long odds. Asked how an agent might catch a problem a human would miss, such as a fuzzy endpoint, a screening error, or a design flaw surfacing mid-study, Tenaerts described the agent's advantage in spotting errors a human might initially miss. "The agent has the ability to see things slightly earlier than a human would," she said. "That likely happens faster than a human can make that connection, so the person can intervene on that issue." She pointed to examples where an agent could point out sites that are falling behind on enrollment, protocol deviations traced to a lab value that repeatedly runs above the range specified in the protocol, and an adverse event emerging sooner on a trend basis. Getting a handle on the complexity can free up humans to focus less on data wrangling and more on interpreting the nuances of a given trial, Getz said. "There are very tactical decisions, like at what point do we need to alert the sites if we've detected a pattern in the deviations," he said. "And then there are major decisions of importance. Should we change the strategy of the study? Do we modify the design in some way? Do we need to address an amendment? What an agentic tool can help do is give the human the opportunity to focus on those higher priority decisions, and a lot of the more mundane ones can be streamlined or managed a lot more effectively." To some extent, the adoption of agents in clinical trials is at an early phase. In an interview with Pharmavoice, Tenaerts cited the complexity of oncology and its high unmet need, and touched on the potential for the model to extend to other trial types. "It makes logical sense that something you do in an oncology program we could probably replicate in other programs. I feel comfortable saying that we can, but we haven't done the model," she said. Where automation is landing in clinical trials today. Over the last couple of years, frontier AI labs have boasted about the ability of their models to do complex tasks, largely unattended. For instance, Anthropic said Mythos "conducted novel genomics research in over a week of largely autonomous work." Google DeepMind similarly said in July that AlphaEvolve, a Gemini-powered agent for designing and optimizing algorithms, "runs unattended, generating and improving candidates at a scale no human team could match." Medable said its agents tend to have a shorter leash. "Most of what the agent does right now is not autonomous," Tenaerts said. She described query resolution as close to the only action it takes on its own: when a field is missing, the agent writes the query, sends it to the site and files it in the TMF, and the CRA sees the record rather than approving it in advance. Everything else follows a recommend-and-review pattern in which the agent surfaces an issue, proposes next best actions and waits. "The agent doesn't suspend the CRA from thinking," she said. "The CRA still needs to be there." She also flagged where the work lands once monitoring speeds up. "If we are getting really efficient at sending out email to sites, we sure hope that the sites will get some help, because if you dump all that stuff on them, that's still a bottleneck, right?" Tenaerts said. "You push the balloon and it goes somewhere else. You need to figure out the whole system." Venu Mallarapu, chief transformation and AI officer at competing clinical data platform eClinical Solutions also put a ceiling on how far deployments have gone. Most eClinical customers are running assistive AI that drafts while a person handles the acting, he said, while the most advanced run scoped agents inside workflows that have been reengineered around them. "There's nobody that is running fully autonomous agents that not only process the data but also make decisions without human involvement," Mallarapu said. "At least I haven't seen that within our customer base."